Enable and scale

Process development and optimization for biotech companies
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A one-stop shop from development to scale up for bioprocesses

Full-suite fermentation and downstream processing services at benchtop and pilot scale. 

Our Services

Fermentation optimization to improve yield
Fermentation optimization to improve yield

Strain testing in conditions replicating commercial manufacturing
Media and process optimization
GRAS oriented process development

Downstream process development to decrease product loss
Downstream process development to decrease product loss

Wide range of DSP unit operations optimization and scaling
Protein purification by multi-stage TFF
Spray drying development and scale up

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Regulatory guidance

Expertise in approval process with FDA
Process towards safety approval
Critical control point identification in process flow

Tech transfer to CMO
Tech transfer to CMO

Connections to large-scale producers, negotiation assistance, and tech transfer oversight for smooth transition to industrial-scale production

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Plant Capabilities

A one-stop shop to bring your process to commercial scale.

Vessels ranging from 1.5L to 1,500L for stepwise scale up

Solid/liquid, liquid/liquid, slurries. Centrifuges, homogenizer, bead mill, chemical lysis. Strong expertise in industrial-scale cell lysis

Multi-stage TFFs, freeze dryers, spray dryers

HPLC, GC, UV, off-gas, mass spectrometer

Fermented Bubbles

Boston Bioprocess and Cauldron Partner to Help Fermentation-based Companies Scale from Lab to Manufacturing

Trupti Khade Categories: News

Boston Bioprocess and Cauldron today announce their partnership which aims to overcome one of the biggest challenges for fermentation-based companies today – economically viable paths to scale from lab to manufacturing.

Boston Bioprocess and Cauldron will work together to create a path to industrial-scale production for companies that would benefit from Cauldron’s continuous fermentation technology.

Cauldron CEO and Co-founder, Michele Stansfield, said “Cauldron and Boston Bioprocess’s partnership supports the ecosystem, bringing together Boston Bioprocess’s best in class process development capabilities with Cauldron’s manufacturing expertise and hyper-fermentation technology.”.

“Together Cauldron and Boston Bioprocess are helping to bridge the valley of death for biotech companies who struggle to make the technology transition from lab to manufacturing.” said Ms Stansfield.

Boston Bioprocess CEO Michael Tai, PhD said the Cauldron and Boston Bioprocess partnership is about finding the best possible combination of technology and assets for each client.

"Transitioning to industrial-scale production is about finding the best partner for a client’s particular strain and particular product. It’s not a one-size-fits-all process, which means that we need to work hard to form a network of talented and reliable CMOs, all of whom can be the best fit for some portion of our client base,” said Dr. Tai.

“Working more closely with Cauldron allows us to minimize the pain of tech transfer and shorten the time to market for those clients that could benefit from Cauldron’s assets and unique technology,” Dr. Tai said.

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