Enable and scale

Process development and optimization for biotech companies
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A one-stop shop from development to scale up for bioprocesses

Full-suite fermentation and downstream processing services at benchtop and pilot scale. 

Our Services

Fermentation optimization to improve yield
Fermentation optimization to improve yield

Strain testing in conditions replicating commercial manufacturing
Media and process optimization
GRAS oriented process development

Downstream process development to decrease product loss
Downstream process development to decrease product loss

Wide range of DSP unit operations optimization and scaling
Protein purification by multi-stage TFF
Spray drying development and scale up

Regulatory guidance
Regulatory guidance

Expertise in approval process with FDA
Process towards safety approval
Critical control point identification in process flow

Tech transfer to CMO
Tech transfer to CMO

Connections to large-scale producers, negotiation assistance, and tech transfer oversight for smooth transition to industrial-scale production

What can we do?

Plant Capabilities

A one-stop shop to bring your process to commercial scale.

Vessels ranging from 1.5L to 1,500L for stepwise scale up

Solid/liquid, liquid/liquid, slurries. Centrifuges, homogenizer, bead mill, chemical lysis. Strong expertise in industrial-scale cell lysis

Multi-stage TFFs, freeze dryers, spray dryers

HPLC, GC, UV, off-gas, mass spectrometer

Fermented Bubbles

Hyfé Scales Production of Mycelium Protein Powder Ahead of Schedule

Boston Bioprocess Categories: News

Hyfé, a climate-tech company unlocking low-cost production of sustainable essential goods, today announced it has scaled production of its mycelium protein to 400L pilot bioreactors since its launch and pre-seed funding last May.

Hyfé is transforming food manufacturing waste streams into fermentation feedstock. Biomanufacturing has the potential to create solutions to some of the most pressing challenges facing humanity. It can enable improvements in health, climate, and quality of life if rendered economically viable. Reducing the cost of production is key to making sustainable bioproducts competitive against subsidized commodities. The feedstocks that power bioproduction represent a high-impact opportunity since they account for up to 50% of fermentation operating expenses and are vulnerable to supply chain disruptions.

Founded in 2021 by former LanzaTech and ExxonMobil engineers, Hyfé is supported by Boston Bioworks and the University of Illinois Bioprocessing Research Laboratory. The Engine, the venture firm spun out of MIT that invests in early-stage Tough Tech companies, led the company’s recent, oversubscribed investment round.

Check out the full article on Business Wire!

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