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Process development and optimization for biotech companies
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A one-stop shop from development to scale up for bioprocesses

Full-suite fermentation and downstream processing services at benchtop and pilot scale. 

Our Services

Fermentation optimization to improve yield
Fermentation optimization to improve yield

Strain testing in conditions replicating commercial manufacturing
Media and process optimization
GRAS oriented process development

Downstream process development to decrease product loss
Downstream process development to decrease product loss

Wide range of DSP unit operations optimization and scaling
Protein purification by multi-stage TFF
Spray drying development and scale up

Regulatory guidance
Regulatory guidance

Expertise in approval process with FDA
Process towards safety approval
Critical control point identification in process flow

Tech transfer to CMO
Tech transfer to CMO

Connections to large-scale producers, negotiation assistance, and tech transfer oversight for smooth transition to industrial-scale production

What can we do?

Plant Capabilities

A one-stop shop to bring your process to commercial scale.

Vessels ranging from 1.5L to 1,500L for stepwise scale up

Solid/liquid, liquid/liquid, slurries. Centrifuges, homogenizer, bead mill, chemical lysis. Strong expertise in industrial-scale cell lysis

Multi-stage TFFs, freeze dryers, spray dryers

HPLC, GC, UV, off-gas, mass spectrometer

Fermented Bubbles

Boston Bio Helps Precision Fermentation Startups Scale Up

Boston Bioprocess Categories: News

In the food protein industry, sustainability, climate change and animal welfare are a growing concern for many consumers, leading to soaring interest in alternative protein. This wide term encompasses a range of technology aiming to provide sustainable alternatives to meat production, such as plant-based meat, fermentation, and cultured meat.

“When you take animals out of the supply chain picture, one of the best ways to produce these ingredients to replace existing animal-based ingredients is fermentation,” said Michael Tai, co-founder and CEO of the U.S. startup Boston Bio. 

However, there is less attention and investment devoted to helping synthetic biology startups scale up their production. This means there are few options to help them advance their process from the lab scale to the point where they can enter commercial production with a contract manufacturing organization (CMO). This was a problem frequently encountered by Tai when he worked as head of bioprocess at the plant-based company Motif FoodWorks, and what led him to launch Boston Bio this year.

“I had seen some of the problems that our own portfolio companies were having scaling up: having trouble finding the right talent, expertise and equipment,” said Boston Bios’ head of finance, Ted Netland, who also serves as an advisor at the alternative protein-focused venture capital (VC) firm Lever VC. “That was what led us to realize that there was an opportunity out there.”

To overcome the bottleneck in scaling up, Boston Bio offers process development services to clients that are developing food products such as meat and dairy proteins, fats, and flavorings. This helps startups to streamline their path to the commercial scale without needing to spend extra cash and time on upgrading their equipment.

In the long term, Boston Bio plans to produce its own proprietary ingredients, and could even branch out into other verticals, such as fragrances and flavors, cosmetics and renewable chemicals.

Read our full feature over on Labiotech!

Hyfé Scales Production of Mycelium Protein Powder Ahead of Schedule

BACKED BY

Levervc VC
Gener8tor
FTW Ventures
Siddhi Capital

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